Glucuronic Acid Conjugation of Chlorinated and Some Unsaturated Alcohols by J. N. Smith and R. T. Williams
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چکیده
Baer, E. & McArthur, C. S. (1944). J. biol. Chem. 154,451. Chargaff, E., Ziff, M. & Rittenberg, D. (1942). J. biol. Chem. 144, 343. Entenman, C., Taurog, A. & Chaikoff, I. L. (1944). J. biol. Chem. 155, 13. Folch, J. (1942). J. biol. Chem. 146, 35. Fo]ch, J., Schneider, H. A. & Van Slyke, D. D. (1940). J. biol. Chem. 133, xxxiii. Fowden, L. (1951). Biochem. J. 48, 327. Hack,'M. H. (1953). Biochem. J. 54, 602. Hanahan, D. J., Turner, M. B. & Jayko, M. E. (1951). J. biol. Chem. 192, 623. Hecht, E. & Mink, C. (1952). Biochim. biophy8. Acta, 8,641. Kirk, E., Page, I. H. & Van Slyke, D. D. (1934). J. biol. Chem. 106, 203. Kline, L., Gegg, J. E. & Sonoda, T. T. (1951). Food Tech., Champaign, 5, 181. Lea, C. H., Hannan, R. S. & Rhodes, D. N. (1951). Biochim. biophy8. Acta, 7, 366. Lea, C. H. & Rhodes, D. N. (1953). Biochem. J. 54, 467. Levine, C. & Chargaff, E. (1951). J. biol. Chem. 192, 465. Moore, S. & Stein, W. H. (1948). J. biol. Chem. 176, 367. Outhouse, E. L. (1937). Biochem. J. 31, 1459. Schmidt, G., Hershman, B. & Thannhauser, S. J. (1945). J. biol. Chem. 161, 523. Taylor, T. W. J. & Baker, W. (1937). Sidgwick'8 Organic Chemi8try of Nitrogen, 2nd ed., p. 172. Oxford: Clarendon Press.
منابع مشابه
Studies in detoxication. 55. The metabolism of alkylbenzenes: (a) glucuronic acid excretion following the administration of alkylbenzenes; (b) elimination of toluene in the expired air of rabbits.
Little is known about the metabolism in the animal body of monoalkylbenzenes other than toluene and ethylbenzene (cf. Williams, 1947). The information available suggests that the n-alkyl side chains undergo w-oxidation followed by $-oxidation of the terminology (Rules of Carbohydrate Nomenclature, J. chem. Soc., 1952, p. 5108), glucosiduronic acids) andthe alcohols asnon-reducing glucuronides. ...
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An account of our studies on the metabolic fate of toluene, ethyl-, i8opropyland tert.-butyl-benzenes has been given in earlier papers (Smith, Smithies & Williams, 1954a, b, c; Robinson, Smith & Williams, 1955; Robinson & Williams, 1955). The present paper deals with n-propyland n-butyl-benzenes. These two compounds were previously studied by Thierfelder & Klenk (1924), who showed that npropylb...
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RESOLUTION of racemic substances as a result of selective assimilation by living organisms is originally due to Pasteur [1858, 1860] who showed that Penicillium glaucum destroyed the d-tartrate in a solution ofammonium racemate leaving the l-isomeride. Examples of the action of micro-organisms in this manner are numerous [see Cohen, 1924]. The mammalian organism also deals with optical antipode...
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Most foreign compounds are conjugated in vivo producing metabolites which are fairly strong organic acids and are readily excreted in either the urine or bile (see Williams & Millburn, 1974). The major conjugation mechanisms in animals are those utilizing glucuronic acid, glucose, sulphate, glycine, cysteine, acetylation and methylation (see Williams, 1968). Glucuronic acid conjugation is the m...
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